2021 U.S. Open men's quarterfinal odds, predictions: Tennis expert reveals Djokovic vs. Berrettini picks

Novak Djokovic's quest for a record-setting 21st Grand Slam title continues Wednesday when the Serbian takes on Matteo Berrettini in the men's quarterfinals at the 2021 U.S. Open. Djokovic is tied with Roger Federer and Rafael Nadal with 20 titles after winning his third straight Grand Slam at Wimbledon in July. Berrettini was the player he beat in the final at the All-England Club, and Djokovic also is seeking to become the first player since Rod Laver in 1969 to win a calendar-year Grand Slam. Djokovic wore down American Jenson Brooksby in Monday's fourth-round matchup, while Berrettini beat Oscar Otte, with both matches going four sets. Djokovic is 3-0 against Berrettini in all-time meetings.

Caesars Sportsbook lists Djokovic as the -800 favorite (risk $800 to win $100) in its latest Djokovic vs. Berrettini odds, with Berrettini the +500 underdog. The over-under for total games is set at 33.5. Before making any 2021 U.S. Open picks, be sure to see the latest tennis predictions from SportsLine's Sean Calvert.

Calvert is the renowned handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1, the last Australian title won by someone other than Djokovic or Roger Federer. In 2019, Calvert took down a huge score on Dominic Thiem winning Indian Wells at 80-1.

And earlier in 2021, he nailed both of his bets for the Wimbledon men's singles final: Djokovic to beat Berrettini three sets to one (+275) and Djokovic to win and both players to win a set (+130). Anyone following his picks is way up.

Now, Calvert has locked in on the 2021 U.S. Open men's quarterfinal matchup featuring Djokovic vs. Berrettini and revealed his best bets. Head to SportsLine to see them.

Djokovic surely saw that Otte had success coming to the net against the Italian, and the world's No. 1 player has hammered Berrettini on his weak backhand in previous matchups. The Italian is still trying to return to form after a thigh injury at Wimbledon, and while Djokovic hasn't been his dominant self, he is far superior in movement and consistency. He simply wears down opponents, and Berrettini has taken just two sets in their meetings this year, both on tie-breaks.

The serves will be the key, and the stats don't go in Berrettini's favor. His big serve is his bread-and-butter, but Djokovic is the best returner he has seen. The Italian has held serve just 76 percent of the time in the past two meetings while breaking Djokovic at only five percent. The numbers from their matches in New York tell a similar story, with Djokovic breaking 41 percent of the time and Berrettini at just 20 percent. Djokovic also is 9-0 in U.S. Open quarterfinals.

How to make Berrettini vs. Djokovic picks

Calvert has studied this matchup in-depth and has found value on a best bet that includes which player will win, and by how many sets. Head to SportsLine to see his best bets.

Who wins Berrettini vs. Djokovic in the U.S. Open 2021 men's quarterfinal? And by how many sets? Visit SportsLine now to see Sean Calvert's best bets, all from a renowned tennis handicapper, and find out.