2022 Hall of Fame Game odds, spread, line: Raiders vs. Jaguars prediction, NFL picks by expert who's 427-344

The Las Vegas Raiders has been perfect in the opening game of the NFL preseason, recording a victory in their previous three appearances in the NFL Hall of Fame Game. It will attempt to improve to 4-0 and earn the distinction of winning as a resident of three different cities when it faces the Jacksonville Jaguars on Thursday in the 2022 NFL Hall of Fame Game. The Raiders, who went 10-7 last season, won the league's preseason opener while in Oakland in 1979 and 2006 while also emerging victorious in 1993, when they were located in Los Angeles. Jacksonville (3-14) made its only appearance in the contest in 1995, losing to Carolina in the first game in franchise history for both teams.

Kickoff from Tom Benson Hall of Fame Stadium in Canton, Ohio is scheduled for 8 p.m. ET. The line is pick'em in the latest Raiders vs. Jaguars odds at Caesars Sportsbook, while the over-under for total points scored is 30.5. Before locking in any Jaguars vs. Raiders picks or 2022 NFL Hall of Fame Game predictions, make sure you check out what SportsLine NFL expert Larry Hartstein has to say.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. Entering the 2022 NFL season, he is 427-344 all-time on NFL sides (plus $3,764 for $100 players), including 394-330 against the spread.

Hartstein went 68-50 ATS (58 percent) and 8-3 on money-line plays last season for a profit of $1,552. Anybody who has been following him is way up.

Now, Hartstein has locked in on Raiders vs. Jaguars from every angle and released a confident against-the-spread pick for the NFL Hall of Fame Game 2022. You can visit SportsLine now to see his picks. Here are several NFL odds and trends for Jaguars vs. Raiders:
• LV: Raiders have won all three of their previous appearances in the Hall of Fame Game
• JAX: Jaguars lost to Carolina in their only previous Hall of Fame Game in 1995

Why the Raiders can cover

Even though both teams likely won't be using many of their starters, Las Vegas could attempt to win at all costs. The reason is new coach Josh McDaniels, who helped New England go 9-2 over its last three preseasons while serving as its offensive coordinator and played in Tom Benson Hall of Fame Stadium over his high-school career. Derek Carr isn't expected to be on the field after he didn't take a single snap last preseason, so McDaniels will get long looks at Nick Mullens and Jarrett Stidham on Thursday.

The 27-year-old Mullens made 16 starts for San Francisco from 2018-20 but just one with Cleveland last season, going 20-for-30 for 147 yards and a touchdown in a 16-14 loss to the Raiders in Week 15. He has completed 64.6 percent of his pass attempts for 4,861 yards with 26 TDs and 22 interceptions in 20 career NFL contests. Stidham spent the last three years with McDaniels in New England and was 24-of-48 passing for 270 yards with two TDs and four picks in eight games.

Why the Jaguars can cover

The long-awaited reunion of former Clemson teammates Trevor Lawrence and Travis Etienne will be delayed a bit longer as new coach Doug Pederson stated the quarterback and running back won't suit up on Thursday. Both players were selected in the first round of the 2021 NFL Draft, but Etienne missed his entire rookie season with a foot injury. Pederson, who guided Philadelphia to its lone Super Bowl championship in 2017, also won't have backup signal-caller C.J. Beathard at his disposal since the 28-year-old is nursing a groin injury.

That means Jake Luton, who is slated to be the Jaguars' third-string quarterback, likely will see plenty of action against the Raiders. The 26-year-old, who was a sixth-round draft pick in 2020, started three games for Jacksonville that season and completed 60-of-110 pass attempts for 624 yards with two touchdowns and six interceptions but was cut prior to the 2021 campaign. Kyle Sloter, who was signed on July 24 after finishing second in the USFL during its 2022 season with 1,798 passing yards in nine games for the New Orleans Breakers, also should take snaps on Thursday.

How to make Raiders vs. Jaguars picks

Hartstein has analyzed this matchup and while we can tell you he's leaning Under on the point total, he has discovered a critical X-factor that has him jumping all over one side of the spread. He's only sharing what it is, and which side to back, at SportsLine.

Who wins the 2022 Hall of Fame Game? And which critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see Larry Hartstein's Raiders vs. Jaguars picks, all from the NFL expert who's 427-344 all-time on NFL sides, and find out.