49ers vs. Packers odds, line: 2022 NFL playoff picks, Divisional round prediction by top model on 137-97 roll

The last four times the Green Bay Packers won the NFC North title, they reached the conference championship game but failed to advance to the Super Bowl. They suffered their first three losses on the road, but fell to Tampa Bay at home last year. The Packers (13-4) will take the first step toward ending the dubious streak on Saturday when they host the San Francisco 49ers (11-7) in the 2022 NFL playoffs. Green Bay has lost its last three postseason meetings with San Francisco, with the most recent defeat taking place on the road in the 2019 NFC Championship Game.

Kickoff from Lambeau Field is set for 8:15 p.m. ET. Green Bay is a 5.5-point favorite in the latest 49ers vs. Packers odds from Caesars Sportsbook, while the over-under for total points scored is 47. Before locking in any Packers vs. 49ers picks, make sure check out the latest NFL playoff predictions and betting advice from SportsLine's proven projection model.

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters the divisional round of the 2021 NFL playoffs on an incredible 137-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn't missed a top-rated pick since Week 14 of the regular season.

The model also ranked in the Top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Packers vs. 49ers on Saturday and just locked in its NFL playoff picks and predictions. You can visit SportsLine now to see the model's picks. Here are the NFL odds and Divisional round betting lines for 49ers vs. Packers:
• GB: Packers are 11-1 against the spread in their last 12 games following a straight-up loss
• SF: 49ers are 6-1 ATS in their last seven contests as underdogs



Why the Packers can cover

Packers receiver Davante Adams has been superb against San Francisco during his career, making 48 catches for 618 yards and five touchdowns in five meetings. Adams registered 132 or more receiving yards in four of those contests, including Green Bay's 30-28 road victory in Week 3 in which he had a season-high 12 receptions for 132 yards and a TD.

While the 49ers have a dual threat on offense in wideout Deebo Samuel, the Packers have one of their own in Aaron Jones. The 27-year-old running back gained 799 yards this season, finishing four behind A.J. Dillon for the team lead, and also was second with a career-high 52 receptions for 391 yards. While Adams topped Green Bay with 11 touchdowns in 2021, Jones was a close second with 10, including six through the air, which matches the total from his first four NFL seasons.

Why the 49ers can cover

San Francisco has plenty of recent postseason success against the Packers, getting past them in the Niners' last three trips to the NFL playoffs. The 49ers were victorious at home in the 2012 divisional round and 2019 conference championship game, while winning in Green Bay in the 2013 wild-card round. They're optimistic about their chances for a fourth straight playoff win over the Packers, as key injured stars appear to be healing.

The 49ers' defense was third overall (310 yards) during the regular season, sixth against the pass (206.5), seventh versus the run (103.5) and fifth in sacks (48).

How to make Packers vs. 49ers picks

SportsLine's model is leaning Under on the point total. In fact, it's calling for 46 total points. It also says one side of the spread cashes in well over 50 percent of simulations. You can only get the model's 49ers vs. Packers picks at SportsLine.

So who wins Packers vs. 49ers on Saturday in the NFL playoffs 2022? And which side of the spread cashes well over 50 percent of the time? Visit SportsLine now to see which side of the Packers vs. 49ers spread to be all over, all from the advanced model that is up more than $7,500 on its top-rated NFL picks, and find out.