Stanford vs. Arizona State odds, line: 2021 college football picks, Week 6 predictions from model on 12-4 run

No. 22 Arizona State and Stanford face off in Pac-12 showdown on Friday night. Arizona State will go for its third win in a row in front of the roaring fans at Sun Devil Stadium. Stanford is hoping to improve to 3-1 in conference play after defeating No. 8 Oregon and USC. Arizona State is currently 2-0 in conference matchups.

Kickoff from Sun Devil Stadium is set for 10:30 p.m. ET. Caesars Sportsbook lists the Sun Devils at -13 in the Stanford vs. Arizona State odds, while the over-under for total points is set at 53. Before finalizing any Arizona State vs. Stanford picks, be sure to see the college football predictions and betting advice from SportsLine's proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,400 for $100 players on its top-rated college football picks against the spread. It also enters Week 6 of the 2021 season on a 12-4 run on all top-rated college football side picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Stanford vs. Arizona State and revealed its CFB picks and predictions. Visit SportsLine now to see the model's picks. Here are the college football odds and betting lines for Arizona State vs. Stanford:
• ASU: The Over is 4-0 in Arizona State's last four conference games
• STAN: The Cardinal are 5-1-1 ATS in their last seven road games

Stanford has outgained its Pac-12 foes in every matchup this season. Sophomore quarterback Tanner McKee has played well in in each game, tossing at least 230 yards with two passing touchdowns. In three conference games, McKee has gone 55 of 91 for 757 yards with eight passing touchdowns.

Stanford averages 348.8 total yards and 6.1 yards per play. Junior receiver Elijah Higgins had his best game of the season against UCLA. Higgins caught five passes for 103 yards with one touchdown. The Texas native averaged a season-high 20.1 yards per reception.

The Sun Devils roll into this matchup with the No. 1 ranked offense in the Pac-12. Arizona State's well-balanced offense averages 442.8 total yards per game. The Sun Devils have a conference-high 18 rushing touchdowns while averaging 203.4 yards per game on the ground. Against UCLA, Arizona State rushed for 178 yards with three touchdowns.

Redshirt senior Rachaad White and sophomore DeaMonte Trayanum led the rushing attack against the Bruins. White had nine carries for 69 yards with two touchdowns, including a 49-yard touchdown run. Trayanum had 16 carries for 68 yards and another score. This running back tandem can give the Stanford defense fits on Friday night.

How to make Arizona State vs. Stanford picks

SportsLine's model is leaning over on the total, projecting 59 combined points. It also has generated an against the spread pick that hits in 60 percent of simulations. You can get the pick over at SportsLine.

So who wins Stanford vs. Arizona State? And which side of the spread hits 60 percent of the time? Visit SportsLine now to see which side of the Arizona State vs. Stanford spread to back, all from the advanced model that is up almost $3,400 on its top-rated college football spread picks, and find out.